Immunogenicity using ElectroChemiLuminesence Technology (MesoScale Discovery)

THE CHALLENGE

Today’s rapid developments in biologics–including proteins, peptides, therapeutic antibodies, and immunotherapeutics–have resulted in new drug development challenges that require an extensive and in-depth understanding of bioanalysis/immunology and the development of GLP, GCLP, and GMP compliant assays.

OUR STATE-OF THE ART FACILITIES  

We offer full-service development of ElectroChemiLuminesence (MSD) for measuring various analytes: drugs, specific antibodies, cytokines, biomarkers, and many others. Texcell can also ensure the assay transfer from the laboratories of its sponsor for optimization, validation & GLP/GCLP/GMP testing.

ADVANTAGES

  • Ability to multiplex until 10 antigens per well;
  • Coating of antigens on MSD plates without alteration of their 3D-structure (passive fixation);
  • Bridging format to have a species-independent assayMSD
  • Titration assay to obtain semi-quantitative results;
  • ECLIA to have a very wide Working Range (6 logs), particularly relevant for specific antibodies titration that vary widely from animal to animal and from time-point to time-point;
  • High sensitivity : i) decoupling between the activation and the measurement of the luminescent signal, ii) signal not altered by complex matrices as serum or plasma (unlike fluorescence);
  • Very fast reading: The QuickPlex SQ120 reads 30 plates per hour

 

ABOUT TEXCELL 

Texcell is your international CRO dedicated to provide GCLP/GLP/GMP biosafety and immunology services to support biopharmaceuticals’ development. We are committed to provide our partners with a flexible and customized service based on our 27 years of expertise.

Customer-oriented company, our scientific teams are at your full disposal, with PhD project managers and an R&D team on hand to optimize existing assays or develop new tests on request.

 

Texcell logoYour customized and trusted analytical and clinical testing partner

More info at www.texcell.com